This triple-combination medication leverages three different mechanisms to lower blood pressure:
Olmesartan medoxomil is an angiotensin II receptor blocker (ARB) that blocks the hormone angiotensin II, which narrows blood vessels, thus promoting blood vessel relaxation and a decrease in blood pressure.
Amlodipine is a calcium channel blocker that prevents calcium from entering the walls of blood vessels, causing them to relax and widen.
Hydrochlorothiazide (HCT) is a diuretic, or "water pill," that helps the kidneys eliminate excess salt and water from the body, further lowering blood pressure.
